WebA cytokeratin rim or perinuclear dot-like staining pattern is characteristic of SCLC and occasionally noted in LCNEC. 26 A significant proportion (>90%) of SCLC and ~50% of LCNEC express TTF-1; however, TTF-1 is not specific for pulmonary SCLC/LCNEC and can be expressed in extrapulmonary NEC. 1,33 Meanwhile, Napsin A staining excludes SCLC but ... WebJan 6, 2024 · The co-staining of NRVMs with DAPI and Ca V α1C confirmed the perinuclear localization (convergence depicted by yellow signal) of the pore-forming subunit (Figure 4B). In NE-treated NRVMs (24 and 48 h), Ca V α1C localization at the perinuclear region persisted (Pearson’s coefficient, r ~ 0.26) and was similar to that observed in untreated ...
ANA Patterns
WebThe pattern of immunohistochemical expression of ALK in EFH in the literature thus far describes both granular cytoplasmic staining and nuclear staining. We present a case of … WebWe present a case of EFH with dot-like Golgi pattern perinuclear ALK expression, a previously undescribed staining pattern. We surmised this unique staining pattern could be due to a novel fusion partner, and using FISH, we confirmed a rearrangement of the ALK (2p23) locus. Further investigation with whole transcriptome sequencing led to the ... shorewest realtors in wisconsin
Differential Diagnosis of Cytokeratin “Dots” - IHC WORLD
WebApr 5, 2024 · This staining pattern is observed regardless of the histological subtype (ductal or lobular), the type of sample (biopsy versus ... both with perinuclear “dot-like” CK20 staining. Therefore, the phenotype of Merkel cell carcinomas is CK7−/CK20+ (“dot-like”), CDX2−, SATB2+, Chromogranin+, Synaptophysin+ and positive for Merkel ... WebAug 29, 2024 · This dual stain has 2 additional diagnostic uses: cytoplasmic staining for WT1 is characteristic of melanoma and some sarcomas, 8 and AE1/AE3 demonstrates a weak, perinuclear “dot-like” pattern in small cell carcinoma. 9 In the majority of cases, this stain is sufficient on its own to differentiate mesothelial from epithelial cells, and to … WebMar 9, 2016 · Thus, the perinuclear, dot-like staining pattern is reliable phenotypic characteristic of FGF23 expression. Similar perinuclear staining patterns of other markers … sand whiting fish