WebPatched is a 12-transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters. Taipale et al. (2002) demonstrated that the function of Ptc is impaired by alterations of residues that are conserved in and required for function of these bacterial transporters. Web1 Jul 2003 · Summary: The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the …
Altered Neural Cell Fates and Medulloblastoma in Mouse patched …
WebThe Shh signaling pathway involves two transmembrane proteins on receiving cell, Patched (Ptc), a 12-transmembrane protein, and Smoothened (Smo), a 7-transmembrane protein … WebPatched (Ptc), the main receptor for Sonic Hedghog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apo... Patched dependence … mary ann shore dies
Unrestricted expression of the Drosophila gene patched allows
Web22 Aug 2002 · Patched is a twelve-transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters; we demonstrate that the function … WebPatched Gene PTC Status UniProtKB unreviewed (TrEMBL) Organism Drosophila ananassae (Fruit fly) Amino acids 448 Protein existence Predicted Annotation score 3/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function GO annotations Expand table Complete GO annotation on QuickGO WebPatched is a twelve-transmembrane protein with homology to bacterial proton-driven transmembrane molecular transporters; the function of Ptc is impaired by alterations of … huntington woods logistics neosho mo