WebFolliculin (FLCN) is a tumor-suppressor protein mutated in the Birt–Hogg–Dubé (BHD) syndrome, which associates with two paralogous proteins, folliculin-interacting protein (FNIP)1 and FNIP2, forming a complex that interacts with … WebFeb 2, 2024 · FNIP1 forms a complex with FNIP2 (612768) and folliculin (FLCN; 607273) that interacts with AMP-activated protein kinase (AMPK; see 602739). FLCN is a …
Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis …
Folliculin (FLCN) functions as a binding partner and uncompetitive inhibitor of Lactate Dehydrogenase-A (LDHA). A flexible loop within the amino-terminus of FLCN controls movement of the LDHA active site loop, tightly regulating its enzyme activity and, consequently, metabolic homeostasis in normal cells. See more The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. … See more Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 at position 11.2. (17p11.2). See more • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports research into BHD syndrome and maintains the world's first website … See more Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin interacting protein 1 (FNIP1) and folliculin interacting … See more • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. Urology. 12 (10): 558–69. doi: • Tee AR, Pause A … See more WebOct 1, 2024 · The reported target of miR-499 is the folliculin interacting protein 1 (Fnip1), a negative regulator of AMP-activated protein kinase (AMPK). Consequently, AMPK is an activator of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). hotter shoes ladies wide fitting
Folliculin - Wikipedia
WebJun 1, 2024 · For the genes involved in the PI3K-Akt signaling pathway, the gene–gene network ( Figure 5 A) showed that 51 genes interacted directly with each other. The results revealed that 53 genes were directly involved, and one gene was indirectly involved in the PI3K-Akt signaling pathway. WebRecent studies using murine models for FLCN, a protein encoded by the FLCN gene, and its two binding partners, folliculin-interacting protein 1 (FNIP1) and folliculin-interacting protein 2 (FNIP2), have uncovered important roles for FLCN, FNIP1 and FNIP2 in cell metabolism, which include AMP-activated protein kinase-mediated energy sensing, … WebLOC127985354 folliculin-interacting protein 1 [ (silver crucian carp)] Gene ID: 127985354, updated on 2-Mar-2024. Summary Other designations. folliculin … hotter shoes login